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Localized dual‐drug delivery from biodegradable scaffolds is an important strategy in tissue engineering. In this study, porous poly(L‐lactide‐co‐glycolide) (PLGA)/β‐tricalcium phosphate scaffolds containing both dexamethasone (Dex) and bovine serum albumin (BSA) were prepared by incorporating Dex‐loaded and BSA‐loaded microspheres into the scaffolds. PLGA microspheres containing Dex or BSA were prepared...
In this work, the novel poly vinyl alcohol/gelatin‐nano‐hydroxyapatite/polyamide6 (PVA‐n‐HA/PA6) bilayered scaffold with biomimetic properties for articular cartilage and subchondral bone is developed. Furthermore, when these osteochondral scaffolds were seeded with induced bone mesenchymal stem cells (BMSCs) and implanted at ectopic sites, showed the potential for an engineered cartilage tissue and...
Human acellular nerve grafts (ANGs) have been rarely used to construct tissue‐engineered nerves compared to the animal‐derived ANGs, and their potential clinical applications were relatively unknown. In this study, it was aimed to investigate the structure and components of a scaffold derived from human peripheral nerve and evaluate its biocompatibility. The human peripheral nerves were processed...
Surgical mesh composed of extracellular matrix promotes healing of difficult soft tissue and orthopedic repairs in preclinical and clinical trials. In this study, a novel extracellular matrix prepared from porcine hydrated dermis was evaluated in an in vivo fascial defect model in sheep. Fascial defects were created, and then acutely repaired with surgical mesh. Healed surgical sites were evaluated...
With pure Ti and pure Zr as controls, the corrosion resistance, ion release behavior, and in vitro biocompatibility of Be‐containing Zr41Ti14Cu12Ni10Be23 bulk metallic glass (BMG) (LM1), Zr44Ti11Cu10Ni10Be25 BMG (LM1b), and Be‐free Zr57Nb5Cu15.4Ni12.6Al10 BMG (LM106) were investigated in terms of electrochemical measurements in simulated body fluid (SBF) with pH value 7.4 and artificial saliva (AS)...
The first part of this review looks at the fundamental properties of hydroxyapatite (HAP), the basic mineral constituent of mammalian hard tissues, including the physicochemical features that govern its formation by precipitation. A special emphasis is placed on the analysis of qualities of different methods of synthesis and of the phase transformations intrinsic to the formation of HAP following...
Scaffolds for tissue engineering require the correct biochemical cues if the seeded cells are to migrate into the scaffold and proliferate. For complex tissues this would require precise patterning of the scaffold structure with the particular biochemical cue required at each location on the scaffold. Electrospray enables the deposition of a wide number of biomolecules onto surfaces and can be used...
Transition metal nanoparticles (NPs) such as silver (Ag) and copper (Cu) have been grafted onto carbon nanotube surface through wet chemical approach leading to the development of densely packed NP decorated carbon nanotubes. Chemically active surface and high‐temperature stability are the basic attributes to use carbon nanotubes as the template for the growth of NPs. Ag NP‐grafted carbon nanotubes...
Poly (methyl methacrylate) (PMMA) bone cement is widely used in vertebral body augmentation procedures such as vertebroplasty and balloon kyphoplasty. Filling high modulus PMMA increases the modulus of filled verterbra, increasing the risk of fracture in the adjacent vertebra. On the other hand, in porous PMMA bone cements, wear particle generation and deterioration of mechanical performance are the...
The use of magnesium and its alloys as biodegradable metallic implant materials requires that their corrosion behavior can be controlled. We tailored the Mg release kinetics and cell adhesion properties of commercially pure Mg by chemical surface treatments in simulated body fluid, in Dulbecco's Modified Eagle's cell culture medium in the presence or absence of fetal bovine serum (FBS), or in 100%...
The use of liquid‐to‐solid curing materials for brain aneurysm embolization has become increasingly attractive, as liquid embolics can be delivered noninvasively and can potentially achieve a higher degree of aneurysm volume occlusion. This study was aimed at characterizing differences in the gelling process of a reverse emulsion, crosslinking polymer system formulated with different types of injectable...
In this work, we investigated the efficacy of PECE‐hydrogel in preventing postsurgical peritoneal adhesions in the rat uterine horn model. Standardized surgical traumas were applied to the peritoneum of the abdominal wall and the uterine horns. PECE hydrogel was applied to the two wound surfaces. Animals were euthanized at different times after surgery, and the gross necropsy findings were documented...
Ovine forestomach matrix (OFM) is a native and functional decellularized extracellular matrix biomaterial that supports cell adhesion and proliferation and is remodeled during the course of tissue regeneration. Small angle X‐ray scattering demonstrated that OFM retains a native collagen architecture (d spacing = 63.5 ± 0.2 nm, orientation index = 20°). The biophysical properties of OFM were further...
Magnesium alloys may potentially be applied as biodegradable metallic materials in cardiovascular stent. However, the high corrosion rate hinders its clinical application. In this study, a new approach was adopted to control the corrosion rate by fabricating a biocompatible micro‐arc oxidation/poly‐L‐lactic acid (MAO/PLLA) composite coating on the magnesium alloy WE42 substrate and the biocompatibility...
Hydroxyapatite coatings were deposited on the titanium substrate by using various content Na3Cit as an organic modifier in electrolytes. The influence of the Na3Cit on the sizes of the HA crystals during electrolytic deposition was investigated under different molar ratio of Na3Cit to calcium ions. The experimental results showed that the size of HA crystal was well controlled by the addition of Na...
Sepsis is a harmful hyper‐inflammatory state characterized by overproduction of cytokines. Removal of these cytokines using an extracorporeal device is a potential therapy for sepsis. We are developing a cytokine adsorption device (CAD) filled with porous polymer beads which efficiently depletes middle‐molecular weight cytokines from a circulating solution. However, removal of one of our targeted...
The different molar ratios of collagen/chitosan were used to be immobilized on polypropylene nonwoven fabrics grafted with N‐isopropyl acrylamide (abbr. PP‐g‐NIPAAm‐i‐Col/Chi). For a controlled immobilizing time and NIPAAm concentration, the collagen/chitosan immobilized values and the antibacterial properties of PP‐g‐NIPAAm‐i‐Col/Chi increased with increasing amount of chitosan in the mixture of...
This study evaluated the suitability of femtosecond laser for microtexturizing cylindrical zirconia dental implants surface. Sixty‐six cylindrical zirconia implants were used and divided into three groups: Control group (with no laser modification), Group A (microgropored texture), and Group B (microgrooved texture). Scanning electron microscopy observation of microgeometries revealed minimal collateral...
Silver nano‐particles (Ag NPs) loaded polyvinyl alcohol (PVA) electro‐spun fibers were fabricated using a combination of microwave‐heated and electro‐spinning methods for wound healing. A thermic process was then applied to resurface and increase the number of the Ag NPs on the surface of the PVA fiber. The diameter of the Ag NPs loaded electrospun PVA (PVA‐Ag) mats were between 100 and 500 nm after...
Al2O3 substrates with controlled porosity were manufactured from nanosized powders obtained by plasma processing. It was observed that when increasing the sintering temperature the overall porosity was decreasing, but the pores got larger. In a second step, Ce stabilized ZrO2 doped hydroxyapatite coatings were pulsed laser deposited onto the Al2O3 substrates. It was shown that the surface morphology,...
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